Mitochondrial and Peroxisomal .BETA.-Oxidation: Enzymes and Regulation.
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چکیده
منابع مشابه
Differential induction of peroxisomal beta-oxidation enzymes by clofibric acid and aspirin in piglet tissues.
Peroxisomal beta-oxidation (POX) of fatty acids is important in lipid catabolism and thermogenesis. To investigate the effects of peroxisome proliferators on peroxisomal and mitochondrial beta-oxidation in piglet tissues, newborn pigs (1-2 days old) were allowed ad libitum access to milk replacer supplemented with 0.5% clofibric acid (CA) or 1% aspirin for 14 days. CA increased ratios of liver ...
متن کاملInhibition of mitochondrial beta-oxidation and peroxisomal stimulation in rodent livers by valproate.
at 4°C. The precipitate was trapped on GF/A filters and putrescine incorporation was measured by liquid scintillation counting. Rat muscle TG was eluted from a DEAE-Sephacel column ( 13 mm X 1 10 mm) with a gradient of 0-0.5 M-NaCI in 40 ml of buffer A. Bovine liver cytosolic TG and human plasma factor XIIIA were eluted as standards. Stepwise extraction of TG resulted in the solubilization of m...
متن کاملPeroxisomal and Mitochondrial Enzymes Involved in Lipid Metabolism – Studies on Function and Regulation
Fatty acids constitute a major part of the energy that we obtain from the diet and are also the principal source for mammals to store energy. To use the incoming or stored fatty acids as energy, the fatty acids needs to be metabolized of which the majority of fatty acids will be degraded by the mitochondrial β-oxidation system that in the end generates energy to the cell in the form of ATP. How...
متن کاملSubstrate selectivities differ for hepatic mitochondrial and peroxisomal beta-oxidation in an Antarctic fish, Notothenia gibberifrons.
Hepatic mitochondrial and peroxisomal beta-oxidation were examined in an Antarctic marine teleost, Notothenia gibberifrons. Enzymic profiles and rates of beta-oxidation by intact organelles were determined by using a range of fatty acyl-CoA substrates to evaluate substrate preferences. Partitioning of beta-oxidation between organelles was estimated. Substrate selectivities are broader for perox...
متن کاملIdentification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid.
DHA (C22:6n-3) is an important PUFA implicated in a number of (patho)physiological processes. For a long time, the exact mechanism of DHA formation has remained unclear, but now it is known that it involves the production of tetracosahexaenoic acid (C24:6n-3) from dietary linolenic acid (C18:3n-3) via a series of elongation and desaturation reactions, followed by beta-oxidation of C24:6n-3 to C...
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ژورنال
عنوان ژورنال: Kagaku To Seibutsu
سال: 1999
ISSN: 0453-073X,1883-6852
DOI: 10.1271/kagakutoseibutsu1962.37.443